Venous blood vessel morphogenesis

Across TCGA patient cohorts, RNA activity of the Venous blood vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA4, NDUFB5, and HIVEP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Venous blood vessel morphogenesis activity versus LAMA4 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAMA4 →	+0.667	+0.131	.002	.001	3	4
OV	NDUFB5 →	-0.442	-0.368	.001	.002	3	4
UCEC	HIVEP2 →	+0.430	+0.633	.002	.005	3	3
PDAC	ARMC1 →	-0.222	-0.416	.003	.002	3	3
PDAC	ADAM8 →	+0.577	+0.475	<.001	.002	3	3
PDAC	ISCA2 →	-0.313	-0.466	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048845 vs LAMA4 — BRCA

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