Venous blood vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Venous blood vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPCAT3, CRYZ, and SUOX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPCAT3 grouped by Venous blood vessel morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LPCAT3 →	+0.572	+0.739	.005	<.001	3	3
CNS	CRYZ →	+0.824	+0.976	.005	.002	3	3
CNS	SUOX →	+0.341	+0.678	.001	.001	3	3
CNS	RPL10 →	-0.523	-0.799	.001	<.001	3	3
CNS	TMEM35B →	+1.039	+1.144	<.001	<.001	3	3
CNS	PDE4A →	+0.885	+0.963	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPCAT3 by Venous blood vessel morphogenesis activity — CNS

Explore this box plot interactively →