Venous blood vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Venous blood vessel morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC13A1, TMPRSS9, and RNF157, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC13A1 grouped by Venous blood vessel morphogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC13A1 →	-0.230	-0.162	.002	<.001	3	4
SOFT_TISSUE	TMPRSS9 →	-0.205	-0.194	.001	.001	2	5
OESOPHAGUS	RNF157 →	-0.109	-0.111	.005	.007	3	3
LUNG_NSCLC_LUAD	GABRB1 →	+0.169	+0.171	<.001	.001	3	3
URINARY_TRACT	SLC6A20 →	-0.147	-0.145	.005	.002	3	3
STOMACH	RSAD1 →	+0.155	+0.208	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC13A1 by Venous blood vessel morphogenesis activity — OESOPHAGUS

Explore this box plot interactively →