Venous blood vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Venous blood vessel morphogenesis pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Palbociclib, FEN1_3940, and DMOG, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Palbociclib grouped by Venous blood vessel morphogenesis-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Palbociclib →	+0.384	+1.693	.001	.029	1	1
BONE	FEN1_3940 →	+0.145	+1.693	.028	.029	1	1
BONE	DMOG →	+0.304	+1.693	.039	.029	1	1
BONE	AKT inhibitor VIII →	+0.945	+1.693	.030	.029	1	1
BONE	Quizartinib →	+0.559	+1.693	.009	.029	1	1
BONE	JW-7-24-1 →	+1.254	+1.693	.004	.029	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Palbociclib by Venous blood vessel morphogenesis activity — BONE

Explore this box plot interactively →