Artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Artery morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, VCL_S795, and FMNL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Artery morphogenesis activity versus RSU1 in BRCA (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSU1 →	+0.433	+0.047	<.001	<.001	3	10
LSCC	VCL_S795 →	+0.619	+0.068	<.001	<.001	3	10
CCRCC	FMNL3 →	+0.419	+0.077	<.001	<.001	3	10
GBM	IGFBP7 →	+0.736	+0.054	<.001	<.001	3	10
OV	BGN →	+1.112	+0.080	<.001	<.001	3	10
LSCC	PCOLCE →	+0.686	+0.074	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048844 vs RSU1 — BRCA

Explore this scatter interactively →