Artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, CNN1, and MYL9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Artery morphogenesis activity versus ACTA2 in OV (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACTA2 →	+2.079	+0.736	<.001	.001	3	8
OV	CNN1 →	+1.216	+0.678	.001	.002	3	8
UCEC	MYL9 →	+1.223	+0.737	.002	.004	3	7
CCRCC	RGS5 →	+1.275	+0.645	.001	<.001	3	7
CCRCC	LMOD1 →	+1.210	+0.599	<.001	.002	3	7
LSCC	MAMDC2 →	+0.672	+0.444	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048844 vs ACTA2 — OV

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