Artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC8B, IFT140, and ZNF177, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHDC8B grouped by Artery morphogenesis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHDC8B →	-0.916	-2.222	.002	<.001	3	3
BLOOD_Lymphoma	IFT140 →	-1.142	-2.083	.002	<.001	3	3
BLOOD_Lymphoma	ZNF177 →	-1.513	-2.077	.006	.003	3	3
BLOOD_Lymphoma	HOOK2 →	-1.166	-2.133	<.001	<.001	3	3
LIVER	DEF8 →	+0.746	+1.048	<.001	<.001	3	3
LARGE_INTESTINE	COPS4 →	+0.817	+0.666	.003	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHDC8B by Artery morphogenesis activity — BLOOD_Lymphoma

Explore this box plot interactively →