Artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS9, NPM3, and RPA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Artery morphogenesis activity versus MRPS9 in KIDNEY (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MRPS9 →	-0.966	-1.356	.003	.002	3	4
SOFT_TISSUE	NPM3 →	-1.049	-1.360	.001	.003	3	4
LIVER	RPA3 →	-0.711	-1.204	.002	.004	3	4
BONE	ERMAP →	+0.877	+1.318	.001	<.001	3	4
BLOOD_Leukemia	DNAJB2 →	-0.735	-0.734	.004	.002	3	4
OVARY	CENATAC →	-0.949	-1.004	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048844 vs MRPS9 — KIDNEY

Explore this scatter interactively →