Positive regulation of axon extension involved in axon guidance

Across TCGA patient cohorts, RNA activity of the Positive regulation of axon extension involved in axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIRT6_T294, U2SURP_S800, and XRN2_S448, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of axon extension involved in axon guidance activity versus SIRT6_T294 in BRCA (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SIRT6_T294 →	-0.486	-0.758	.001	<.001	3	3
BRCA	U2SURP_S800 →	-0.651	-0.806	<.001	<.001	3	3
BRCA	XRN2_S448 →	-0.632	-0.599	<.001	<.001	3	3
BRCA	CFH →	+0.381	+0.571	.002	<.001	3	3
BRCA	CPB2 →	+0.568	+0.739	<.001	<.001	3	3
BRCA	HABP2 →	+0.498	+0.591	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048842 vs SIRT6_T294 — BRCA

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