Positive regulation of axon extension involved in axon guidance

Across TCGA cell cohorts, RNA activity of the Positive regulation of axon extension involved in axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM210A, PHIP, and DMXL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM210A grouped by Positive regulation of axon extension involved in axon guidance-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM210A →	-0.668	-1.629	.009	<.001	3	5
LUNG_SCLC	PHIP →	+0.993	+1.201	.003	.003	2	6
CNS	DMXL1 →	+0.523	+0.900	.004	.001	3	4
BONE	HACE1 →	+0.966	+1.871	<.001	<.001	3	4
LARGE_INTESTINE	MAD2L1BP →	+0.476	+0.995	<.001	.004	3	4
LARGE_INTESTINE	C9orf72 →	+1.040	+1.084	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM210A by Positive regulation of axon extension involved in axon guidance activity — LUNG_SCLC

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