Otolith development

Across TCGA patient cohorts, RNA activity of the Otolith development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR19, VDAC2_S115, and SLC16A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otolith development activity versus WDR19 in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR19 →	+0.246	+0.083	.002	<.001	3	6
PDAC	VDAC2_S115 →	-0.531	-0.055	.002	.001	3	6
CCRCC	SLC16A1 →	-0.473	-0.060	.001	.008	3	5
GBM	SNTB2_S208 →	+0.705	+0.088	<.001	<.001	3	5
BRCA	BBS7 →	+0.387	+0.050	<.001	<.001	3	5
LSCC	WDR35 →	+0.190	+0.060	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048840 vs WDR19 — GBM

Explore this scatter interactively →