Otolith development

Across TCGA patient cohorts, RNA activity of the Otolith development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A4, GMDS, and CNTN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otolith development activity versus SLC44A4 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC44A4 →	+1.486	+0.171	<.001	<.001	3	4
LUAD	GMDS →	+0.403	+0.123	.005	.003	3	3
CCRCC	CNTN3 →	+0.845	+0.176	<.001	.003	3	3
BRCA	EHMT2-AS1 →	+0.389	+0.127	<.001	.005	3	3
UCEC	TSNAXIP1 →	+0.830	+0.197	.006	.002	3	3
UCEC	PIH1D2 →	+0.571	+0.207	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048840 vs SLC44A4 — CCRCC

Explore this scatter interactively →