Otolith development

Across TCGA cell cohorts, RNA activity of the Otolith development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCEA3, ZNF571, and ZNF280B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCEA3 grouped by Otolith development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TCEA3 →	-2.430	-1.643	<.001	.001	3	5
BLOOD_Lymphoma	ZNF571 →	-1.377	-1.569	<.001	.006	3	4
BLOOD_Lymphoma	ZNF280B →	-1.017	-2.188	.009	<.001	2	5
UPPER_AERODIGESTIVE_TRACT	IL31RA →	-1.198	-1.322	<.001	.004	3	4
CNS	SAP18 →	+0.498	+0.771	.005	.006	3	3
BLOOD_Lymphoma	CZIB →	-0.459	-1.981	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCEA3 by Otolith development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →