Otolith development

Across TCGA cell cohorts, RNA activity of the Otolith development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HRH4, S100A1, and GP2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HRH4 grouped by Otolith development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HRH4 →	+0.204	+1.417	<.001	<.001	3	2
SKIN	S100A1 →	+0.237	+1.193	.004	<.001	3	2
SKIN	GP2 →	+0.182	+1.193	.004	<.001	3	2
SKIN	LRG1 →	+0.180	+1.283	.001	<.001	3	2
SKIN	TMEM11 →	+0.275	+1.193	.003	<.001	3	2
LUNG_SCLC	DEK →	-0.168	-1.080	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HRH4 by Otolith development activity — BREAST

Explore this box plot interactively →