Otolith development

Across TCGA cell cohorts, RNA activity of the Otolith development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSI2, PGLS, and ZWILCH, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otolith development activity versus MSI2 in BLOOD_Leukemia (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MSI2 →	-1.665	-0.729	.002	.004	3	3
BONE	PGLS →	-0.937	-1.193	.003	<.001	3	3
BONE	ZWILCH →	+1.530	+1.278	.003	.001	3	3
BONE	NOXA1 →	-0.590	-1.193	.001	<.001	3	3
BREAST	ZNF48 →	+1.432	+1.417	<.001	<.001	3	3
SKIN	ELMO3 →	-0.413	-1.211	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048840 vs MSI2 — BLOOD_Leukemia

Explore this scatter interactively →