Erythrocyte development

Across TCGA patient cohorts, RNA activity of the Erythrocyte development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CACNA2D1, ELMO1, and RPL5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte development activity versus CACNA2D1 in OV (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CACNA2D1 →	+0.629	+0.049	<.001	<.001	3	6
OV	ELMO1 →	+0.407	+0.062	.002	<.001	3	5
OV	RPL5 →	-0.195	-0.043	.002	.001	3	5
COAD	DCN →	+0.785	+0.038	<.001	.002	3	5
COAD	ENPP1 →	+0.560	+0.037	.001	<.001	3	5
GBM	EPB41L2 →	+0.515	+0.056	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048821 vs CACNA2D1 — OV

Explore this scatter interactively →