Erythrocyte development

Across TCGA cell cohorts, RNA activity of the Erythrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, GOLGA6L4, and AIDA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte development activity versus G6PD in LUNG_NSCLC_LUSC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	G6PD →	+3.514	+0.336	<.001	<.001	3	5
KIDNEY	GOLGA6L4 →	+0.794	+0.331	.005	.007	3	4
KIDNEY	AIDA →	-1.312	-0.464	<.001	<.001	3	4
KIDNEY	MCUB →	-1.242	-0.562	.001	<.001	3	4
KIDNEY	HSF4 →	+1.802	+0.444	.008	<.001	3	4
LUNG_NSCLC_LUAD	TRPA1 →	+1.302	+0.424	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048821 vs G6PD — LUNG_NSCLC_LUSC

Explore this scatter interactively →