Positive regulation of hair follicle maturation

Across TCGA patient cohorts, RNA activity of the Positive regulation of hair follicle maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB2, CRTAP, and MMP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hair follicle maturation activity versus TGFB2 in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TGFB2 →	+0.768	+0.205	<.001	<.001	3	6
PDAC	CRTAP →	+0.418	+0.098	<.001	.003	2	6
BRCA	MMP14 →	+0.444	+0.062	<.001	<.001	3	5
PDAC	P3H4 →	+0.480	+0.099	<.001	.002	3	5
BRCA	P4HA2 →	+0.767	+0.084	<.001	<.001	3	5
CCRCC	DENND2B_S105 →	+0.438	+0.475	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048818 vs TGFB2 — GBM

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