Positive regulation of hair follicle maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of hair follicle maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CUBN, AGTRAP, and EDIL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CUBN grouped by Positive regulation of hair follicle maturation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CUBN →	-0.300	-1.657	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	AGTRAP →	+0.206	+1.594	.001	.003	3	4
KIDNEY	EDIL3 →	-0.423	-1.317	<.001	.005	3	4
BREAST	MRPS5 →	-0.245	-0.819	<.001	<.001	3	4
BREAST	DPY30 →	-0.319	-1.519	<.001	<.001	3	4
SOFT_TISSUE	RRN3 →	-0.341	-1.399	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CUBN by Positive regulation of hair follicle maturation activity — STOMACH

Explore this box plot interactively →