Regulation of dendrite morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of dendrite morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SEPTIN11, and B3GLCT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite morphogenesis activity versus RPL5 in LUAD (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL5 →	-0.240	-0.054	<.001	<.001	3	7
BRCA	SEPTIN11 →	+0.386	+0.027	<.001	<.001	3	7
PDAC	B3GLCT →	+0.277	+0.021	<.001	.001	3	7
BRCA	TIMP2 →	+0.805	+0.035	<.001	<.001	3	7
BRCA	TSC22D1 →	+0.301	+0.029	.002	<.001	3	7
LSCC	CLPX →	-0.344	-0.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048814 vs RPL5 — LUAD

Explore this scatter interactively →