Regulation of dendrite morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of dendrite morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLSCR4, APLF, and FAM180A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite morphogenesis activity versus PLSCR4 in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLSCR4 →	+0.500	+0.796	<.001	<.001	3	4
LUAD	APLF →	+0.310	+0.866	.003	<.001	3	4
LUAD	FAM180A →	+0.447	+0.650	.006	.004	3	4
LUAD	BAIAP2-DT →	+0.460	+0.603	.002	.002	3	4
HNSC	NCALD →	+0.751	+0.391	.001	.001	3	4
HNSC	THSD7B →	+0.872	+0.338	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048814 vs PLSCR4 — LUAD

Explore this scatter interactively →