Regulation of dendrite morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of dendrite morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT2, ZNF837, and RAB32, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite morphogenesis activity versus B4GALT2 in PANCREAS (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	B4GALT2 →	-0.650	-0.198	.001	.009	3	4
BONE	ZNF837 →	+1.168	+0.288	.005	<.001	3	4
LARGE_INTESTINE	RAB32 →	+2.084	+0.477	<.001	.004	3	3
CNS	ERICH1 →	+0.535	+0.590	.003	.007	2	4
CNS	KTI12 →	-0.550	-0.672	.008	.005	3	3
PANCREAS	PARK7 →	-0.879	-0.317	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048814 vs B4GALT2 — PANCREAS

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