Genitalia development

Across TCGA patient cohorts, RNA activity of the Genitalia development pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT5A, ASH1L, and SBF2, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genitalia development activity versus WNT5A in TGCT (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	WNT5A →	+1.723	+0.056	<.001	<.001	3	25
THYM	ASH1L →	+1.248	+0.053	<.001	<.001	3	25
THYM	SBF2 →	+1.387	+0.049	<.001	<.001	3	25
THYM	ZCCHC14 →	+1.459	+0.052	<.001	<.001	3	25
THYM	DLG5 →	+1.984	+0.055	<.001	<.001	3	25
TGCT	ZNF827 →	+0.921	+0.048	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048806 vs WNT5A — TGCT

Explore this scatter interactively →