Genitalia development

Across TCGA patient cohorts, RNA activity of the Genitalia development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF703, AFF4_S620, and NIPBL_S892, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genitalia development activity versus ZNF703 in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF703 →	+0.807	+0.806	<.001	<.001	3	5
BRCA	AFF4_S620 →	+0.995	+0.781	<.001	<.001	3	5
LSCC	NIPBL_S892 →	+1.671	+0.774	<.001	<.001	3	4
OV	NIPBL_T735 →	+1.128	+1.114	<.001	<.001	3	4
HNSC	SAFB →	+0.178	+0.878	.002	<.001	3	3
BRCA	SH3KBP1_S445 →	-0.863	-0.899	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048806 vs ZNF703 — BRCA

Explore this scatter interactively →