Genitalia development

Across TCGA cell cohorts, RNA activity of the Genitalia development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D32, ZFP36L2, and MYO1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D32 grouped by Genitalia development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TBC1D32 →	+0.678	+1.213	.001	<.001	3	5
LARGE_INTESTINE	ZFP36L2 →	+1.115	+0.646	.003	.003	3	4
LARGE_INTESTINE	MYO1A →	+2.618	+0.892	.002	.003	3	4
SOFT_TISSUE	DKK3 →	-3.180	-1.341	.001	.008	3	4
LUNG_NSCLC_LUAD	ADAM19 →	-1.797	-0.810	.002	.002	3	4
PANCREAS	BCO1 →	+1.194	+0.954	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D32 by Genitalia development activity — SKIN

Explore this box plot interactively →