Genitalia development

Across TCGA cell cohorts, RNA activity of the Genitalia development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRRAP, DPF1, and ANGPTL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genitalia development activity versus TRRAP in PANCREAS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TRRAP →	+1.299	+1.409	<.001	.002	3	4
PANCREAS	DPF1 →	+1.170	+1.019	.004	.004	3	4
PANCREAS	ANGPTL6 →	+0.176	+0.948	.001	<.001	3	4
PANCREAS	POM121C →	+0.990	+1.049	<.001	.004	3	4
KIDNEY	CRHBP →	+0.433	+1.761	<.001	<.001	3	4
BLOOD_Leukemia	CCM2 →	+0.736	+0.589	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048806 vs TRRAP — PANCREAS

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