Animal organ maturation

Across TCGA patient cohorts, RNA activity of the Animal organ maturation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAG1, CALHM5, and GREM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Animal organ maturation activity versus IRAG1 in OV (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRAG1 →	+1.285	+0.490	<.001	.001	3	8
OV	CALHM5 →	+1.084	+0.484	<.001	<.001	3	8
OV	GREM1 →	+1.539	+0.346	<.001	.001	3	7
OV	ACTA2 →	+2.112	+0.485	<.001	<.001	3	7
OV	PDLIM3 →	+1.213	+0.368	.001	<.001	3	7
COAD	LMOD1 →	+1.264	+0.726	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048799 vs IRAG1 — OV

Explore this scatter interactively →