Animal organ maturation

Across TCGA cell cohorts, RNA activity of the Animal organ maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCNX4, FRAT2, and STRN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCNX4 grouped by Animal organ maturation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PCNX4 →	+1.196	+1.167	<.001	.005	3	5
LARGE_INTESTINE	FRAT2 →	-1.055	-0.996	.002	.002	3	4
BONE	STRN →	+1.137	+1.432	<.001	.004	3	4
LUNG_SCLC	CYP20A1 →	+0.766	+1.294	<.001	<.001	3	4
LUNG_SCLC	ATG5 →	+0.733	+1.212	<.001	<.001	3	4
BONE	PPP2R3A →	+1.655	+0.872	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCNX4 by Animal organ maturation activity — LUNG_SCLC

Explore this box plot interactively →