Calcium ion-regulated exocytosis of neurotransmitter

Across TCGA patient cohorts, RNA activity of the Calcium ion-regulated exocytosis of neurotransmitter pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYT7, PTPN7, and INPP5D_S243, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion-regulated exocytosis of neurotransmitter activity versus SYT7 in GBM (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYT7 →	+1.035	+0.142	<.001	<.001	3	6
GBM	PTPN7 →	-0.370	-0.113	<.001	<.001	3	6
BRCA	INPP5D_S243 →	-0.511	-0.045	.003	.008	3	5
LSCC	SASH3 →	-0.341	-0.040	.001	.009	3	5
LSCC	BIN2_S273 →	-0.446	-0.035	.008	.009	3	5
GBM	CLIP2_S42 →	+0.915	+0.130	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048791 vs SYT7 — GBM

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