Calcium ion-regulated exocytosis of neurotransmitter

Across TCGA cell cohorts, RNA activity of the Calcium ion-regulated exocytosis of neurotransmitter pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL6ST, MYO1C, and ANTXR2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL6ST grouped by Calcium ion-regulated exocytosis of neurotransmitter-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IL6ST →	-1.330	-0.724	<.001	.007	3	3
OESOPHAGUS	MYO1C →	-1.161	-0.962	.001	.009	3	3
LUNG_NSCLC_LUAD	ANTXR2 →	-1.952	-0.610	.003	.006	3	3
LUNG_NSCLC_LUSC	ST6GALNAC6 →	-1.639	-0.954	<.001	.005	3	3
LUNG_NSCLC_LUSC	CTSB →	-2.462	-1.460	.009	.009	3	3
SOFT_TISSUE	KCNG2 →	-0.358	-0.916	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL6ST by Calcium ion-regulated exocytosis of neurotransmitter activity — OESOPHAGUS

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