Calcium ion-regulated exocytosis of neurotransmitter

Across TCGA cell cohorts, RNA activity of the Calcium ion-regulated exocytosis of neurotransmitter pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNDC16, IMPACT, and ZNF385A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion-regulated exocytosis of neurotransmitter activity versus TXNDC16 in LUNG_SCLC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TXNDC16 →	+1.390	+0.920	.001	.004	3	5
BLOOD_Leukemia	IMPACT →	+2.249	+0.919	.003	.009	3	4
BLOOD_Leukemia	ZNF385A →	+1.472	+0.963	<.001	.003	2	5
BLOOD_Leukemia	KCNH4 →	+0.352	+1.100	<.001	<.001	3	3
LUNG_SCLC	RHOXF1 →	+0.549	+1.033	<.001	<.001	3	3
LUNG_SCLC	ARHGEF7 →	+1.837	+1.095	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048791 vs TXNDC16 — LUNG_SCLC

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