Maintenance of presynaptic active zone structure

Across TCGA patient cohorts, RNA activity of the Maintenance of presynaptic active zone structure pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK8_S451, RFTN1, and TNS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of presynaptic active zone structure activity versus DOCK8_S451 in LUAD (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DOCK8_S451 →	-0.512	-0.048	<.001	<.001	3	6
CCRCC	RFTN1 →	-0.491	-0.073	<.001	<.001	3	5
BRCA	TNS3 →	-0.207	-0.044	.008	.007	3	5
COAD	BDH2 →	-0.331	-0.068	<.001	<.001	3	5
GBM	DAB2 →	-0.518	-0.113	<.001	<.001	3	5
GBM	S100A4 →	-0.669	-0.122	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048790 vs DOCK8_S451 — LUAD

Explore this scatter interactively →