Maintenance of presynaptic active zone structure

Across TCGA cell cohorts, RNA activity of the Maintenance of presynaptic active zone structure pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETD5, DNAJC15, and SHF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SETD5 grouped by Maintenance of presynaptic active zone structure-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SETD5 →	-0.697	-1.074	.001	.004	3	4
BONE	DNAJC15 →	+3.985	+2.254	.004	<.001	3	4
BLOOD_Leukemia	SHF →	-1.392	-1.769	.002	<.001	3	4
BONE	PTPRJ →	+3.047	+1.966	.001	.007	3	3
BLOOD_Lymphoma	RNF2 →	-1.290	-1.938	.008	<.001	3	3
CNS	SLC26A5 →	-0.022	-0.976	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SETD5 by Maintenance of presynaptic active zone structure activity — LUNG_SCLC

Explore this box plot interactively →