Tissue remodeling

Across TCGA patient cohorts, RNA activity of the Tissue remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFPT2, RAB31, and MYL9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tissue remodeling activity versus GFPT2 in OV (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GFPT2 →	+1.416	+0.351	<.001	.001	3	6
OV	RAB31 →	+0.958	+0.254	<.001	<.001	3	5
COAD	MYL9 →	+1.225	+0.740	<.001	<.001	3	5
OV	AKT3 →	+0.997	+0.280	<.001	<.001	3	5
OV	OMD →	+1.445	+0.278	<.001	<.001	3	5
OV	CACNA2D1 →	+0.780	+0.290	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048771 vs GFPT2 — OV

Explore this scatter interactively →