Mesenchymal cell differentiation

Across TCGA cell cohorts, RNA activity of the Mesenchymal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB7B, AGMAT, and LSM14B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell differentiation activity versus ZBTB7B in SOFT_TISSUE (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZBTB7B →	+1.075	+0.296	.006	.005	3	4
KIDNEY	AGMAT →	+1.543	+0.268	<.001	<.001	3	4
BLOOD_Leukemia	LSM14B →	-0.738	-0.119	<.001	.003	3	4
OVARY	ZNF492 →	-1.184	-0.189	<.001	.003	3	4
BLOOD_Leukemia	SGSM3 →	-1.047	-0.111	<.001	.007	3	4
BLOOD_Leukemia	BCL7A →	-1.606	-0.151	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048762 vs ZBTB7B — SOFT_TISSUE

Explore this scatter interactively →