Branching morphogenesis of a nerve

pathway activity — cross-omics
GO:0048755Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Branching morphogenesis of a nerve pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDPD1, EPX, and UBXN10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAGDPD1 →+0.571+0.441.001<.00135
HNSCEPX →+0.303+0.272.008.00634
BRCAUBXN10 →+1.151+0.466.002.00934
HNSCSERPINB7 →-1.669-0.307<.001<.00134
BRCAS100A10 →-1.288-0.661<.001<.00134
LUADKAT6B →+0.196+0.522.004.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration