Pigment granule organization

Across TCGA patient cohorts, RNA activity of the Pigment granule organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, ARHGAP24_S415, and RENBP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment granule organization activity versus AIF1 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AIF1 →	+0.584	+0.036	.001	<.001	3	9
HNSC	ARHGAP24_S415 →	+0.468	+0.064	.001	.001	3	9
UCEC	RENBP →	+0.528	+0.060	<.001	.002	3	8
LSCC	GIMAP7 →	+0.537	+0.050	<.001	<.001	3	8
UCEC	DOCK11 →	+0.453	+0.067	.001	<.001	3	7
HNSC	MAP1S →	+0.218	+0.042	.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048753 vs AIF1 — GBM

Explore this scatter interactively →