Pigment granule organization

Across TCGA patient cohorts, RNA activity of the Pigment granule organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CABP4, EFCC1, and SGO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment granule organization activity versus CABP4 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CABP4 →	+0.905	+0.372	<.001	.004	3	4
UCEC	EFCC1 →	+0.646	+0.177	.003	.008	3	3
UCEC	SGO1 →	-0.585	-0.123	.001	.003	3	3
BRCA	TPRG1 →	+1.417	+0.313	.002	.002	3	3
BRCA	PLPP6 →	+0.523	+0.296	<.001	.002	3	3
UCEC	RNU6-444P →	+0.758	+0.188	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048753 vs CABP4 — BRCA

Explore this scatter interactively →