Pigment granule organization

Across TCGA cell cohorts, RNA activity of the Pigment granule organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT8B, TGFBRAP1, and DCAF16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment granule organization activity versus WNT8B in LUNG_SCLC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	WNT8B →	-0.639	-0.204	.007	.001	3	4
LUNG_SCLC	TGFBRAP1 →	-0.589	-0.171	<.001	.004	3	3
LUNG_SCLC	DCAF16 →	-0.802	-0.191	.002	.005	2	4
CNS	ZFHX2 →	-0.688	-0.253	<.001	<.001	3	3
CNS	CHRNA9 →	-1.548	-0.248	<.001	.008	3	3
CNS	ZNF664 →	-0.604	-0.220	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048753 vs WNT8B — LUNG_SCLC

Explore this scatter interactively →