Semicircular canal morphogenesis

Across TCGA patient cohorts, RNA activity of the Semicircular canal morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFI30, SAMSN1_S107, and TNFAIP8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semicircular canal morphogenesis activity versus IFI30 in LSCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IFI30 →	-0.540	-0.094	<.001	<.001	3	7
LSCC	SAMSN1_S107 →	-0.491	-0.065	.001	.001	2	6
LSCC	TNFAIP8 →	-0.545	-0.098	<.001	<.001	3	5
LSCC	ADA2 →	-0.620	-0.082	<.001	<.001	3	5
LSCC	APOBR →	-0.558	-0.089	<.001	<.001	3	5
LSCC	BTK →	-0.713	-0.091	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048752 vs IFI30 — LSCC

Explore this scatter interactively →