Semicircular canal morphogenesis

Across TCGA cell cohorts, RNA activity of the Semicircular canal morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD7, TBX3, and EYA1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHD7 grouped by Semicircular canal morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CHD7 →	-0.473	-1.505	<.001	<.001	3	13
BLOOD_Lymphoma	TBX3 →	-0.590	-1.897	.009	.009	2	10
OVARY	EYA1 →	-0.215	-1.127	.005	.003	3	7
BLOOD_Myeloma	FGF10 →	-0.428	-1.581	.006	.001	3	7
BONE	COMT →	-0.210	-2.009	<.001	<.001	3	7
BLOOD_Myeloma	TBX1 →	-0.290	-1.042	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHD7 by Semicircular canal morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →