Semicircular canal morphogenesis

Across TCGA cell cohorts, RNA activity of the Semicircular canal morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNL3, RGS11, and IL1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNL3 grouped by Semicircular canal morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GNL3 →	-0.216	-0.939	.007	.007	3	5
BREAST	RGS11 →	-0.180	-1.103	<.001	<.001	3	4
SKIN	IL1A →	-0.291	-0.143	.004	.004	2	4
CNS	KCNJ16 →	-0.207	-0.148	.002	.008	3	3
BLOOD_Myeloma	BMX →	-0.288	-1.581	.002	<.001	3	3
BONE	GNG13 →	-0.327	-0.306	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNL3 by Semicircular canal morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →