Smooth muscle tissue development

Across TCGA cell cohorts, RNA activity of the Smooth muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAIP1, PNPLA3, and FRAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAIP1 grouped by Smooth muscle tissue development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAIP1 →	+0.923	+1.445	<.001	<.001	3	5
CNS	PNPLA3 →	-1.307	-1.056	.002	<.001	2	5
BREAST	FRAT2 →	+1.187	+0.966	<.001	<.001	3	4
BREAST	CPLANE1 →	-1.142	-1.193	.001	<.001	3	4
OESOPHAGUS	TRAM2 →	-1.225	-0.960	.004	.005	3	4
BREAST	NEBL →	+1.832	+0.820	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAIP1 by Smooth muscle tissue development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →