Positive regulation of skeletal muscle fiber development

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle fiber development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIM1, PXN, and RIPK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRIM1 grouped by Positive regulation of skeletal muscle fiber development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CRIM1 →	-2.968	-1.581	<.001	.004	3	5
OVARY	PXN →	-1.085	-0.875	.002	.003	3	5
SOFT_TISSUE	RIPK1 →	-1.102	-1.513	.005	.003	3	4
LIVER	MYH9 →	-2.181	-1.376	<.001	.006	3	4
LIVER	CAV1 →	-4.284	-1.069	<.001	.006	3	4
LIVER	AHNAK →	-1.571	-1.378	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRIM1 by Positive regulation of skeletal muscle fiber development activity — BLOOD_Myeloma

Explore this box plot interactively →