Positive regulation of skeletal muscle fiber development

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle fiber development pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMPPA, MAP3K19, and FOLH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GMPPA grouped by Positive regulation of skeletal muscle fiber development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GMPPA →	+0.145	+0.163	.003	.002	3	4
KIDNEY	MAP3K19 →	+0.347	+1.862	<.001	<.001	3	3
KIDNEY	FOLH1 →	-0.152	-1.643	.006	.002	3	3
SOFT_TISSUE	TNPO1 →	+0.298	+2.022	.004	<.001	3	3
SOFT_TISSUE	CENPA →	+0.331	+2.147	<.001	<.001	3	3
SOFT_TISSUE	SUZ12 →	-0.485	-1.640	.007	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GMPPA by Positive regulation of skeletal muscle fiber development activity — STOMACH

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