Regulation of skeletal muscle fiber development

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle fiber development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NIBAN2_S681, NIBAN2_S696, and PLEKHG2_S1261, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle fiber development activity versus NIBAN2_S681 in UCEC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NIBAN2_S681 →	+0.673	+0.282	<.001	.001	3	6
LUAD	NIBAN2_S696 →	+0.552	+0.197	<.001	<.001	2	6
OV	PLEKHG2_S1261 →	+0.771	+0.507	<.001	<.001	3	4
UCEC	CHD9_T2013 →	+0.774	+0.497	<.001	.003	3	3
GBM	NIBAN2 →	+0.479	+0.127	<.001	<.001	3	3
GBM	OSTF1 →	+0.319	+0.126	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048742 vs NIBAN2_S681 — UCEC

Explore this scatter interactively →