Regulation of skeletal muscle fiber development

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle fiber development pathway is significantly associated with the drug response of multiple features, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AZD6738, Pazopanib, and JNJ38877605, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AZD6738 grouped by Regulation of skeletal muscle fiber development-low versus -high activity in OVARY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AZD6738 →	+0.543	+0.325	.043	.027	3	1
OVARY	Pazopanib →	+0.963	+0.325	.001	.027	3	1
OVARY	JNJ38877605 →	+0.393	+0.325	.012	.027	3	1
OVARY	A-83-01 →	+0.340	+0.325	.025	.027	1	2
OVARY	Dasatinib →	-2.006	-0.325	.007	.027	1	1
OVARY	Cetuximab →	-1.639	-0.424	.005	.042	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD6738 by Regulation of skeletal muscle fiber development activity — OVARY

Explore this box plot interactively →