Sebaceous gland development

Across TCGA patient cohorts, RNA activity of the Sebaceous gland development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMAD4, MYO1F, and MUC5AC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sebaceous gland development activity versus SMAD4 in LUAD (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMAD4 →	+0.207	+0.085	<.001	<.001	3	4
BRCA	MYO1F →	-0.305	-0.052	.001	<.001	3	4
COAD	MUC5AC →	+1.227	+0.044	.005	.001	3	4
CCRCC	S100A11 →	-0.333	-0.056	<.001	<.001	3	4
CCRCC	CAVIN2_S364 →	+0.419	+0.059	<.001	<.001	3	4
OV	AP1G1 →	-0.212	-0.066	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048733 vs SMAD4 — LUAD

Explore this scatter interactively →