Sebaceous gland development

Across TCGA patient cohorts, RNA activity of the Sebaceous gland development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF26, SETP6, and CLDN12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sebaceous gland development activity versus ZNF26 in COAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF26 →	+0.172	+0.414	.008	.001	3	3
COAD	SETP6 →	+0.097	+0.476	.005	.001	3	3
LUAD	CLDN12 →	+0.512	+0.252	.001	<.001	3	3
LUAD	PAIP1 →	+0.384	+0.286	<.001	<.001	3	3
LUAD	MSMO1 →	+0.391	+0.245	.006	.002	3	3
BRCA	SP3 →	+0.434	+0.274	.008	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048733 vs ZNF26 — COAD

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