Sebaceous gland development

Across TCGA cell cohorts, RNA activity of the Sebaceous gland development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOSL2, IGF2R, and SQLE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOSL2 grouped by Sebaceous gland development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FOSL2 →	+1.894	+1.248	<.001	.002	3	4
BLOOD_Leukemia	IGF2R →	-1.691	-1.808	.001	<.001	3	4
OESOPHAGUS	SQLE →	+1.798	+1.656	<.001	<.001	3	4
BONE	EYA3 →	-0.963	-2.065	<.001	.001	3	4
LUNG_NSCLC_LUAD	FOXP1 →	-1.186	-1.416	<.001	<.001	3	3
LUNG_NSCLC_LUAD	FBXW9 →	-0.933	-1.337	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOSL2 by Sebaceous gland development activity — SOFT_TISSUE

Explore this box plot interactively →